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Reference Websites

Targeting the biology of ageing with mTOR inhibitors to improve ...

The study drug was found to be safe and well-tolerated across trials and ... decreases the incidence or severity of viral infections in older adults.

www.thelancet.com
Strategies for targeting senescent cells in human disease | Nature ...

Oct 7, 2021 ... This Review summarizes current research on cellular senescence ... hepatic, infectious, musculoskeletal and endocrine diseases29,39,40,41,42 ...

www.nature.com
Aging and aging-related diseases: from molecular mechanisms to ...

Dec 16, 2022 ... Furthermore, thorough research on the pathogenesis of aging to identify interventions that promote health and longevity (such as caloric ...

www.nature.com
Emerging roles of SIRT6 in human diseases and its modulators - Liu ...

Dec 16, 2020 ... Studies using SIRT6-deficient mice revealed aging associated degenerative ... Moreover, a chemical biology study revealed that the SIRT6 ...

onlinelibrary.wiley.com
T and B‐cell signaling in activated PI3K delta syndrome: From ...

Aug 12, 2019 ... In this article, we discuss how studies on the human genetic disorder “Activated PI3K-delta syndrome” and mouse models of this disease ...

onlinelibrary.wiley.com
Targeting the biology of aging with mTOR inhibitors | Nature Aging

8 days ago ... Beginning 20 years ago, researchers discovered a role for mTORC1 ... The risk of infectious diseases associated with higher doses of ...

www.nature.com
Regulation of autophagy as a therapy for immunosenescence ...

Feb 12, 2019 ... Moreover, a recent study described that p16INKa as a senescent marker ... of infections and tissue damage, supporting age-related diseases.

onlinelibrary.wiley.com
Cellular senescence and senolytics: the path to the clinic | Nature ...

Aug 11, 2022 ... Senescent cells accumulate during aging and at pathogenic sites of multiple disorders and diseases. After the first reports of senolytic drugs ( ...

www.nature.com
Cellular senescence: the good, the bad and the unknown | Nature ...

Aug 3, 2022 ... The resulting chronic inflammation is associated with loss of kidney function and complications such as cardiovascular disease and infections.

www.nature.com
COVID‐19 and neurodegeneration: The mitochondrial connection ...

Oct 11, 2022 ... SARS-CoV-2 infection is the primary cause of the coronavirus disease 2019 ... Detection of the virus even in the most detailed studies ...

onlinelibrary.wiley.com

AI-Generated Project Ideas

  1. An investigation into the effects of PI3K inhibitors on cellular senescence in breast cancer cells
  2. The role of senescence in the pathogenesis and treatment of infectious diseases
  3. A study of the impact of biological factors on the development and spread of infectious diseases
  4. The effects of different variables on the expression of PI3K in prostate cancer cells